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Target Snapshot

CHEMBL2094128 Target Snapshot

Cyclin-dependent kinase 2/cyclin A · PROTEIN COMPLEX · Homo sapiens

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1,907Compounds
277Assays
2Approved Drugs
1,494.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P24941. Use UniProt P24941 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P24941 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cyclin-dependent kinase 2/cyclin A as ChEMBL target CHEMBL2094128, mapped to UniProt P24941. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cyclin-dependent kinase 2/cyclin A
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2094128
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P24941
Cyclin-dependent kinase 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cyclin-dependent kinase 2/cyclin A is the right protein anchor across sources, using UniProt P24941 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameCyclin-dependent kinase 2/cyclin A
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP24941
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCyclin-dependent kinase 2
UniProt AccessionP24941
Component TypeProtein
Sequence Length298 aa

Cyclin-dependent kinase 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cyclin-dependent kinase 2/cyclin A, mapped to UniProt P24941. ChEMBL maps the protein component as Cyclin-dependent kinase 2. Sequence length is 298 aa.

Mapped IDP24941
Review nameCyclin-dependent kinase 2/cyclin A
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
4
Phase III
10
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC501,402.0
KI67.0
EC5025.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2312187 9.7 Ki 0.2 Preclinical
CHEMBL360520 9.52 IC50 0.3 Preclinical
CHEMBL363607 9.52 IC50 0.3 Preclinical
CHEMBL363130 9.4 IC50 0.4 Preclinical
CHEMBL261720 9.3 IC50 0.5 Preclinical
CHEMBL382690 9.22 IC50 0.6 Preclinical
CHEMBL1270713 9.0 IC50 1.0 Preclinical
CHEMBL1270818 9.0 IC50 1.0 Preclinical
CHEMBL1271330 9.0 IC50 1.0 Preclinical
CHEMBL2312182 9.0 Ki 1.0 Preclinical
Distribution

pChEMBL Value Distribution

121
5.0
149
5.5
177
6.0
148
6.5
156
7.0
116
7.5
61
8.0
33
8.5
12
9.0
3
9.5
pChEMBL
Assay Landscape

Assay Landscape

277
Total Assays
1,104
Tested Compounds
3
Assay Types
Binding — 274 assays, 1,104 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 263 952 6.4
cell-based format 10 116 6.4
assay format 1 36 7.4
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 0 —
Toxicity — 1 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 11 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine