GABA-A receptor; alpha-2/beta-3/gamma-2 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P18507. Use UniProt P18507 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18507 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit gamma-2
Review this target as GABA-A receptor; alpha-2/beta-3/gamma-2, mapped to UniProt P18507. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit gamma-2. Sequence length is 475 aa.
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This review treats GABA-A receptor; alpha-2/beta-3/gamma-2 as ChEMBL target CHEMBL2094130, mapped to UniProt P18507. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | GABA-A receptor; alpha-2/beta-3/gamma-2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P18507 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit gamma-2 |
| UniProt Accession | P18507 |
| Component Type | Protein |
| Sequence Length | 475 aa |
Gamma-aminobutyric acid receptor subunit gamma-2
Review this target as GABA-A receptor; alpha-2/beta-3/gamma-2, mapped to UniProt P18507. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit gamma-2. Sequence length is 475 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3144849 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL3144696 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL3144697 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL19732 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL3144841 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL3144615 | 9.77 | Ki | 0.17 | Preclinical |
| CHEMBL3144698 | 9.68 | Ki | 0.21 | Preclinical |
| CHEMBL375742 | 9.6 | Ki | 0.25 | Preclinical |
| CHEMBL200177 | 9.52 | Ki | 0.3 | Clinical |
| CHEMBL1783282 | 9.51 | Ki | 0.309 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 63 | 359 | 7.5 |
| protein complex format | 14 | 158 | 7.4 |
| assay format | 2 | 22 | 7.3 |
| single protein format | 1 | 3 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 12 | 12 | 5.0 |
| assay format | 4 | 0 | — |