GABA-A receptor; anion channel · PROTEIN COMPLEX GROUP · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q8BHJ7. Use UniProt Q8BHJ7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8BHJ7 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit alpha-5
Review this target as GABA-A receptor; anion channel, mapped to UniProt Q8BHJ7. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-5. Sequence length is 463 aa.
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This review treats GABA-A receptor; anion channel as ChEMBL target CHEMBL2094133, mapped to UniProt Q8BHJ7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | GABA-A receptor; anion channel |
| Target Type | PROTEIN COMPLEX GROUP |
| Organism | Mus musculus |
| UniProt | Q8BHJ7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit alpha-5 |
| UniProt Accession | Q8BHJ7 |
| Component Type | Protein |
| Sequence Length | 463 aa |
Gamma-aminobutyric acid receptor subunit alpha-5
Review this target as GABA-A receptor; anion channel, mapped to UniProt Q8BHJ7. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-5. Sequence length is 463 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL10450 | 9.6 | IC50 | 0.25 | Preclinical |
| CHEMBL10438 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL12 | 7.92 | IC50 | 12.0 | Approved |
| CHEMBL203226 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL204424 | 6.76 | IC50 | 175.0 | Preclinical |
| CHEMBL205569 | 6.76 | IC50 | 175.0 | Preclinical |
| CHEMBL379949 | 6.61 | EC50 | 245.47 | Preclinical |
| CHEMBL427379 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL207538 | 6.06 | EC50 | 870.96 | Approved |
| CHEMBL210767 | 6.03 | EC50 | 933.25 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 18 | 1 | — |
| protein complex format | 9 | 7 | 5.5 |
| assay format | 5 | 18 | 5.9 |
| tissue-based format | 5 | 2 | 9.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 11 | 9 | 4.8 |
| organism-based format | 4 | 0 | — |