DNA gyrase · PROTEIN COMPLEX · Escherichia coli
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As of 2026-09-14Protein identity stays anchored to UniProt P0AES6. Use UniProt P0AES6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0AES6 as the stable identity anchor, then attach disease evidence before program review.
DNA gyrase subunit B
Review this target as DNA gyrase, mapped to UniProt P0AES6. ChEMBL maps the protein component as DNA gyrase subunit B. Sequence length is 804 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA gyrase as ChEMBL target CHEMBL2094139, mapped to UniProt P0AES6. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether DNA gyrase is the right protein anchor across sources, using UniProt P0AES6 as the stable mapping.
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| Preferred Name | DNA gyrase |
| Target Type | PROTEIN COMPLEX |
| Organism | Escherichia coli |
| UniProt | P0AES6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA gyrase subunit B |
| UniProt Accession | P0AES6 |
| Component Type | Protein |
| Sequence Length | 804 aa |
DNA gyrase subunit B
Review this target as DNA gyrase, mapped to UniProt P0AES6. ChEMBL maps the protein component as DNA gyrase subunit B. Sequence length is 804 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4757242 | 9.68 | IC50 | 0.21 | Preclinical |
| CHEMBL4784687 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL3357980 | 9.54 | IC50 | 0.29 | Preclinical |
| CHEMBL4758336 | 9.54 | IC50 | 0.29 | Preclinical |
| CHEMBL4743844 | 9.51 | IC50 | 0.31 | Preclinical |
| CHEMBL4764566 | 9.44 | IC50 | 0.36 | Preclinical |
| CHEMBL3357561 | 9.42 | IC50 | 0.38 | Preclinical |
| CHEMBL4776319 | 9.37 | IC50 | 0.43 | Preclinical |
| CHEMBL4779288 | 9.28 | IC50 | 0.53 | Preclinical |
| CHEMBL4798551 | 9.28 | IC50 | 0.52 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 161 | 648 | 6.2 |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 18 | 4 | 6.5 |
| organism-based format | 3 | 0 | — |