Cyclooxygenase · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Cyclooxygenase shows approved-linked disease relevance led by rheumatic disease. 5 more disease programs remain visible in the same review block. 23 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P35354. Start with rheumatic disease, then reuse UniProt P35354 as the stable protein anchor across project notes and exports.
Start with rheumatic disease, then reuse UniProt P35354 as the stable protein anchor across project notes and exports.
Cyclooxygenase shows approved-linked disease relevance led by rheumatic disease. 5 more disease programs remain visible in the same review block. 23 linked drugs remain visible in the same block.
Start review with rheumatic disease because it currently carries approved-linked support. Linked drugs include ACEMETACIN, APAZONE, BENZYDAMINE, DEXIBUPROFEN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProstaglandin G/H synthase 2
Review this target as Cyclooxygenase, mapped to UniProt P35354. ChEMBL maps the protein component as Prostaglandin G/H synthase 2. Sequence length is 604 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclooxygenase as ChEMBL target CHEMBL2094253, mapped to UniProt P35354. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Cyclooxygenase is the right protein anchor across sources, using UniProt P35354 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why rheumatic disease is currently framed as approved-linked support. It currently carries 23 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Cyclooxygenase |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P35354 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prostaglandin G/H synthase 2 |
| UniProt Accession | P35354 |
| Component Type | Protein |
| Sequence Length | 604 aa |
Prostaglandin G/H synthase 2
Review this target as Cyclooxygenase, mapped to UniProt P35354. ChEMBL maps the protein component as Prostaglandin G/H synthase 2. Sequence length is 604 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Cyclooxygenase shows approved-linked disease relevance led by rheumatic disease. 5 more disease programs remain visible in the same review block.
Start review with rheumatic disease because it currently carries approved-linked support. Linked drugs include ACEMETACIN, APAZONE, BENZYDAMINE, DEXIBUPROFEN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL314337 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL8846 | 8.24 | IC50 | 5.7 | Clinical |
| CHEMBL6 | 8.0 | IC50 | 10.0 | Approved |
| CHEMBL4169347 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL4173526 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL4177185 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL435907 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL4162061 | 7.48 | IC50 | 33.0 | Preclinical |
| CHEMBL266100 | 7.47 | IC50 | 34.0 | Preclinical |
| CHEMBL4172740 | 7.47 | IC50 | 34.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 83 | 37 | 5.0 |
| tissue-based format | 22 | 7 | 4.2 |
| assay format | 19 | 82 | 6.4 |
| cell-based format | 12 | 4 | 6.2 |
| organism-based format | 6 | 0 | — |
| microsome format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 12 | 4 | 5.5 |
| tissue-based format | 4 | 2 | 4.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 5 | 0 | — |