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Target Snapshot

CHEMBL2094257 Target Snapshot

Adenosine A2 receptor · PROTEIN FAMILY · Homo sapiens

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870Compounds
108Assays
3Approved Drugs
365.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Adenosine A2 receptor shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P29275. Start with cardiovascular disease, then reuse UniProt P29275 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with cardiovascular disease, then reuse UniProt P29275 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
cardiovascular disease

Adenosine A2 receptor shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with cardiovascular disease because it currently carries approved-linked support. Linked drugs include PENTOXIFYLLINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Adenosine A2 receptor as ChEMBL target CHEMBL2094257, mapped to UniProt P29275. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Adenosine A2 receptor
PROTEIN FAMILY · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2094257
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P29275
Adenosine receptor A2b
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Adenosine A2 receptor is the right protein anchor across sources, using UniProt P29275 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why cardiovascular disease is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameAdenosine A2 receptor
Target TypePROTEIN FAMILY
OrganismHomo sapiens
UniProtP29275
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAdenosine receptor A2b
UniProt AccessionP29275
Component TypeProtein
Sequence Length332 aa

Adenosine receptor A2b

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Adenosine A2 receptor, mapped to UniProt P29275. ChEMBL maps the protein component as Adenosine receptor A2b. Sequence length is 332 aa.

Mapped IDP29275
Review nameAdenosine A2 receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Adenosine A2 receptor shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
cardiovascular disease
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOXIFYLLINE
Late clinical Phase III
avascular necrosis
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOXIFYLLINE
Late clinical Phase III
brachial plexus neuropathy
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOXIFYLLINE
Late clinical Phase III
chronic kidney disease
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOXIFYLLINE
Late clinical Phase III
chronic renal failure syndrome
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOXIFYLLINE
Late clinical Phase III
cirrhosis of liver
1 linked drug · 1 direct · 1 efficacy
Linked drugPENTOXIFYLLINE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with cardiovascular disease because it currently carries approved-linked support. Linked drugs include PENTOXIFYLLINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasecardiovascular disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

3
Approved
3
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC5011.0
KI199.0
EC50155.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL605668 9.72 EC50 0.1905 Preclinical
CHEMBL1950554 9.59 EC50 0.257 Clinical
CHEMBL611607 9.49 EC50 0.3236 Preclinical
CHEMBL2311197 9.41 EC50 0.389 Preclinical
CHEMBL2094089 9.35 EC50 0.4467 Preclinical
CHEMBL2113592 9.33 EC50 0.4677 Preclinical
CHEMBL605878 9.3 EC50 0.5012 Preclinical
CHEMBL608663 9.16 EC50 0.6918 Preclinical
CHEMBL331372 9.13 EC50 0.7413 Preclinical
CHEMBL606080 9.06 EC50 0.871 Preclinical
Distribution

pChEMBL Value Distribution

30
5.0
42
5.5
33
6.0
39
6.5
34
7.0
27
7.5
38
8.0
22
8.5
8
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

ADENOSINE
CHEMBL477
Approved 1989
Properties Compare Identifier
Assay Landscape

Assay Landscape

108
Total Assays
182
Tested Compounds
2
Assay Types
Binding — 70 assays, 182 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 32 18 7.0
assay format 14 71 5.7
cell membrane format 13 80 6.0
cell-based format 9 13 6.3
tissue-based format 2 0 —
Functional — 38 assays, 125 compounds
BAO Format Assays Compounds Avg pChEMBL
cell membrane format 17 0 —
assay format 13 123 7.7
cell-based format 3 0 —
cell-free format 3 0 —
tissue-based format 2 2 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine