Phosphodiesterase 1 · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P54750. Use UniProt P54750 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54750 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Review this target as Phosphodiesterase 1, mapped to UniProt P54750. ChEMBL maps the protein component as Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A. Sequence length is 535 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphodiesterase 1 as ChEMBL target CHEMBL2095150, mapped to UniProt P54750. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Phosphodiesterase 1 is the right protein anchor across sources, using UniProt P54750 as the stable mapping.
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| Preferred Name | Phosphodiesterase 1 |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P54750 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
| UniProt Accession | P54750 |
| Component Type | Protein |
| Sequence Length | 535 aa |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Review this target as Phosphodiesterase 1, mapped to UniProt P54750. ChEMBL maps the protein component as Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A. Sequence length is 535 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4095097 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL43232 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL183857 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL361582 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL369081 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL434135 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL5270640 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL182179 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL39285 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL4067682 | 7.58 | IC50 | 26.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 65 | 166 | 5.7 |
| assay format | 5 | 5 | 5.0 |
| cell-based format | 5 | 40 | 5.2 |
| tissue-based format | 3 | 50 | 4.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 2 | 7.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 2 | 1 | 5.6 |
| cell-based format | 1 | 2 | 5.8 |