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Target Snapshot

CHEMBL2095168 Target Snapshot

Hemoglobin HbA · PROTEIN COMPLEX · Homo sapiens

214Compounds
56Assays
0Approved Drugs
9.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Hemoglobin HbA shows approved-linked disease relevance led by anemia. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P69905. Start with anemia, then reuse UniProt P69905 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with anemia, then reuse UniProt P69905 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
anemia

Hemoglobin HbA shows approved-linked disease relevance led by anemia. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with anemia because it currently carries approved-linked support. Linked drugs include VOXELOTOR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Hemoglobin HbA as ChEMBL target CHEMBL2095168, mapped to UniProt P69905. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Hemoglobin HbA
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2095168
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P69905
Hemoglobin subunit alpha
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Hemoglobin HbA is the right protein anchor across sources, using UniProt P69905 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why anemia is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHemoglobin subunit alpha
UniProt AccessionP69905
Component TypeProtein
Sequence Length142 aa

Hemoglobin subunit alpha

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Hemoglobin HbA, mapped to UniProt P69905. ChEMBL maps the protein component as Hemoglobin subunit alpha. Sequence length is 142 aa.

Mapped IDP69905
Review nameHemoglobin HbA
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Hemoglobin HbA shows approved-linked disease relevance led by anemia. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
anemia
1 linked drug · 1 direct · 1 efficacy
Linked drugVOXELOTOR
Approved-linked Approved
anemia (phenotype)
1 linked drug · 1 direct · 1 efficacy
Linked drugVOXELOTOR
Approved-linked Approved
sickle cell anemia
1 linked drug · 1 direct · 1 efficacy
Linked drugVOXELOTOR
Late clinical Phase III
breast cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugEFAPROXIRAL
Late clinical Phase III
lung cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugEFAPROXIRAL
Late clinical Phase III
neoplasm
1 linked drug · 1 direct · 1 efficacy
Linked drugEFAPROXIRAL
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with anemia because it currently carries approved-linked support. Linked drugs include VOXELOTOR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseanemia
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Assay Mix

Activity Type Distribution

IC509.0
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

56
Total Assays
0
Tested Compounds
2
Assay Types
Binding — 43 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 22 0
assay format 16 0
tissue-based format 5 0
Functional — 13 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 12 0
tissue-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine