Sodium channel alpha subunits; brain (Types I, II, III) · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P04775. Use UniProt P04775 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04775 as the stable identity anchor, then attach disease evidence before program review.
Sodium channel protein type 2 subunit alpha
Review this target as Sodium channel alpha subunits; brain (Types I, II, III), mapped to UniProt P04775. ChEMBL maps the protein component as Sodium channel protein type 2 subunit alpha. Sequence length is 2005 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium channel alpha subunits; brain (Types I, II, III) as ChEMBL target CHEMBL2095171, mapped to UniProt P04775. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sodium channel alpha subunits; brain (Types I, II, III) |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P04775 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sodium channel protein type 2 subunit alpha |
| UniProt Accession | P04775 |
| Component Type | Protein |
| Sequence Length | 2005 aa |
Sodium channel protein type 2 subunit alpha
Review this target as Sodium channel alpha subunits; brain (Types I, II, III), mapped to UniProt P04775. ChEMBL maps the protein component as Sodium channel protein type 2 subunit alpha. Sequence length is 2005 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL332257 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL118603 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL331513 | 7.72 | IC50 | 19.0 | Preclinical |
| CHEMBL117331 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL119139 | 7.58 | IC50 | 26.0 | Preclinical |
| CHEMBL331942 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL120306 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL30008 | 7.28 | Ki | 53.0 | Clinical |
| CHEMBL92977 | 7.19 | Ki | 64.0 | Preclinical |
| CHEMBL334104 | 7.16 | IC50 | 70.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 14 | 35 | 6.0 |
| tissue-based format | 14 | 38 | 4.8 |
| cell membrane format | 5 | 60 | 6.2 |
| subcellular format | 3 | 1 | — |
| protein format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| subcellular format | 8 | 9 | 6.6 |
| tissue-based format | 7 | 1 | — |
| assay format | 2 | 27 | 5.7 |