Adenylate cyclase · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt D4A3N4. Use UniProt D4A3N4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt D4A3N4 as the stable identity anchor, then attach disease evidence before program review.
Adenylate cyclase type 1
Review this target as Adenylate cyclase, mapped to UniProt D4A3N4. ChEMBL maps the protein component as Adenylate cyclase type 1. Sequence length is 1119 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adenylate cyclase as ChEMBL target CHEMBL2095179, mapped to UniProt D4A3N4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Adenylate cyclase |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | D4A3N4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Adenylate cyclase type 1 |
| UniProt Accession | D4A3N4 |
| Component Type | Protein |
| Sequence Length | 1119 aa |
Adenylate cyclase type 1
Review this target as Adenylate cyclase, mapped to UniProt D4A3N4. ChEMBL maps the protein component as Adenylate cyclase type 1. Sequence length is 1119 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL412488 | 9.57 | EC50 | 0.27 | Preclinical |
| CHEMBL437648 | 8.28 | Kd | 5.248 | Preclinical |
| CHEMBL428460 | 8.26 | Kd | 5.495 | Preclinical |
| CHEMBL439885 | 8.2 | EC50 | 6.3 | Preclinical |
| CHEMBL552736 | 7.66 | Ki | 22.0 | Preclinical |
| CHEMBL269490 | 7.64 | EC50 | 23.0 | Preclinical |
| CHEMBL1467585 | 7.5 | EC50 | 32.0 | Preclinical |
| CHEMBL369006 | 7.48 | Ki | 33.0 | Preclinical |
| CHEMBL263603 | 7.38 | EC50 | 41.8 | Preclinical |
| CHEMBL442135 | 7.33 | EC50 | 47.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 25 | 14 | 7.0 |
| assay format | 7 | 10 | 6.6 |
| tissue-based format | 6 | 1 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 4 | 6.1 |