Carbonic anhydrase · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Carbonic anhydrase shows approved-linked disease relevance led by epilepsy. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P00918. Start with epilepsy, then reuse UniProt P00918 as the stable protein anchor across project notes and exports.
Start with epilepsy, then reuse UniProt P00918 as the stable protein anchor across project notes and exports.
Carbonic anhydrase shows approved-linked disease relevance led by epilepsy. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with epilepsy because it currently carries approved-linked support. Linked drugs include SULTHIAME. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCarbonic anhydrase 2
Review this target as Carbonic anhydrase, mapped to UniProt P00918. ChEMBL maps the protein component as Carbonic anhydrase 2. Sequence length is 260 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Carbonic anhydrase as ChEMBL target CHEMBL2095180, mapped to UniProt P00918. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Carbonic anhydrase is the right protein anchor across sources, using UniProt P00918 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why epilepsy is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Carbonic anhydrase |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P00918 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Carbonic anhydrase 2 |
| UniProt Accession | P00918 |
| Component Type | Protein |
| Sequence Length | 260 aa |
Carbonic anhydrase 2
Review this target as Carbonic anhydrase, mapped to UniProt P00918. ChEMBL maps the protein component as Carbonic anhydrase 2. Sequence length is 260 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Carbonic anhydrase shows approved-linked disease relevance led by epilepsy. 1 more disease program remain visible in the same review block.
Start review with epilepsy because it currently carries approved-linked support. Linked drugs include SULTHIAME. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL282157 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL4434661 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL4460315 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL4552380 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL804 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL20 | 9.1 | Ki | 0.8 | Approved |
| CHEMBL65455 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL423848 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL19 | 7.7 | IC50 | 20.0 | Approved |
| CHEMBL20 | 7.7 | IC50 | 20.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 17 | 45 | 7.1 |
| assay format | 4 | 0 | — |
| organism-based format | 2 | 0 | — |