Tubulin · PROTEIN COMPLEX GROUP · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Tubulin shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 40 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P68371. Start with neoplasm, then reuse UniProt P68371 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P68371 as the stable protein anchor across project notes and exports.
Tubulin shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 40 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ANETUMAB RAVTANSINE, ANG1005, ANVATABART OPADOTIN, BELANTAMAB MAFODOTIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTubulin beta-4B chain
Review this target as Tubulin, mapped to UniProt P68371. ChEMBL maps the protein component as Tubulin beta-4B chain. Sequence length is 445 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tubulin as ChEMBL target CHEMBL2095182, mapped to UniProt P68371. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Tubulin is the right protein anchor across sources, using UniProt P68371 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 40 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Tubulin |
| Target Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
| UniProt | P68371 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tubulin beta-4B chain |
| UniProt Accession | P68371 |
| Component Type | Protein |
| Sequence Length | 445 aa |
Tubulin beta-4B chain
Review this target as Tubulin, mapped to UniProt P68371. ChEMBL maps the protein component as Tubulin beta-4B chain. Sequence length is 445 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tubulin shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ANETUMAB RAVTANSINE, ANG1005, ANVATABART OPADOTIN, BELANTAMAB MAFODOTIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5194719 | 10.26 | IC50 | 0.0551 | Preclinical |
| CHEMBL5203711 | 9.75 | IC50 | 0.176 | Preclinical |
| CHEMBL553025 | 9.51 | IC50 | 0.308 | Approved |
| CHEMBL39541 | 9.3 | IC50 | 0.5 | Clinical |
| CHEMBL5169466 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL4575066 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL2024544 | 8.59 | IC50 | 2.6 | Preclinical |
| CHEMBL5410715 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL107 | 8.52 | IC50 | 3.0 | Approved |
| CHEMBL67 | 8.52 | IC50 | 3.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 812 | 82 | 6.0 |
| protein complex format | 631 | 785 | 5.7 |
| tissue-based format | 10 | 0 | — |
| assay format | 8 | 48 | 5.2 |
| subcellular format | 3 | 0 | — |
| cell membrane format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 21 | 149 | 5.7 |
| cell-based format | 6 | 19 | 5.8 |
| organism-based format | 1 | 21 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 0 | — |