Collagenase · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P08253. Use UniProt P08253 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08253 as the stable identity anchor, then attach disease evidence before program review.
72 kDa type IV collagenase
Review this target as Collagenase, mapped to UniProt P08253. ChEMBL maps the protein component as 72 kDa type IV collagenase. Sequence length is 660 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Collagenase as ChEMBL target CHEMBL2095216, mapped to UniProt P08253. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Collagenase |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P08253 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 72 kDa type IV collagenase |
| UniProt Accession | P08253 |
| Component Type | Protein |
| Sequence Length | 660 aa |
72 kDa type IV collagenase
Review this target as Collagenase, mapped to UniProt P08253. ChEMBL maps the protein component as 72 kDa type IV collagenase. Sequence length is 660 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL74670 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL73763 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL439944 | 8.59 | IC50 | 2.6 | Preclinical |
| CHEMBL306412 | 8.31 | IC50 | 4.9 | Preclinical |
| CHEMBL123775 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL293503 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL306726 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL332755 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL340461 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL432223 | 8.3 | Ki | 5.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 5 | 132 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 4 | 4.6 |