Muscarinic acetylcholine receptors; M1 & M2 · SELECTIVITY GROUP · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P11229. Use UniProt P11229 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P11229 as the stable identity anchor, then attach disease evidence before program review.
Muscarinic acetylcholine receptor M1
Review this target as Muscarinic acetylcholine receptors; M1 & M2, mapped to UniProt P11229. ChEMBL maps the protein component as Muscarinic acetylcholine receptor M1. Sequence length is 460 aa.
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This review treats Muscarinic acetylcholine receptors; M1 & M2 as ChEMBL target CHEMBL2095219, mapped to UniProt P11229. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Muscarinic acetylcholine receptors; M1 & M2 |
| Target Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
| UniProt | P11229 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M1 |
| UniProt Accession | P11229 |
| Component Type | Protein |
| Sequence Length | 460 aa |
Muscarinic acetylcholine receptor M1
Review this target as Muscarinic acetylcholine receptors; M1 & M2, mapped to UniProt P11229. ChEMBL maps the protein component as Muscarinic acetylcholine receptor M1. Sequence length is 460 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL287868 | 9.55 | Ki | 0.279 | Preclinical |
| CHEMBL517712 | 9.17 | Ki | 0.683 | Approved |
| CHEMBL6001460 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL5941178 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL6001161 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL5777432 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL5958580 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL5763957 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL5835409 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL5987707 | 7.3 | IC50 | 50.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 32 | 268 | 6.7 |
| cell-based format | 9 | 0 | — |
| assay format | 8 | 0 | — |
| tissue-based format | 3 | 2 | 9.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |