Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL2095228 Target Snapshot

Potassium-transporting ATPase · PROTEIN COMPLEX · Sus scrofa

426Compounds
35Assays
2Approved Drugs
377.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P18434. Use UniProt P18434 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P18434 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Potassium-transporting ATPase as ChEMBL target CHEMBL2095228, mapped to UniProt P18434. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Potassium-transporting ATPase
PROTEIN COMPLEX · Sus scrofa
As of 2026-09-14
ChEMBL target ID
CHEMBL2095228
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P18434
Potassium-transporting ATPase subunit beta
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Potassium-transporting ATPase is the right protein anchor across sources, using UniProt P18434 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPotassium-transporting ATPase subunit beta
UniProt AccessionP18434
Component TypeProtein
Sequence Length290 aa

Potassium-transporting ATPase subunit beta

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Potassium-transporting ATPase, mapped to UniProt P18434. ChEMBL maps the protein component as Potassium-transporting ATPase subunit beta. Sequence length is 290 aa.

Mapped IDP18434
Review namePotassium-transporting ATPase
OrganismSus scrofa
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50377.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL96835 7.75 IC50 18.0 Preclinical
CHEMBL315880 7.72 IC50 19.0 Preclinical
CHEMBL92087 7.72 IC50 19.0 Preclinical
CHEMBL330495 7.68 IC50 21.0 Preclinical
CHEMBL92833 7.68 IC50 21.0 Preclinical
CHEMBL92757 7.66 IC50 22.0 Preclinical
CHEMBL330247 7.62 IC50 24.0 Preclinical
CHEMBL92510 7.55 IC50 28.0 Preclinical
CHEMBL420621 7.5 IC50 32.0 Preclinical
CHEMBL330283 7.47 IC50 34.0 Preclinical
Distribution

pChEMBL Value Distribution

53
5.0
91
5.5
45
6.0
20
6.5
20
7.0
9
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

35
Total Assays
325
Tested Compounds
1
Assay Types
Binding — 35 assays, 325 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 29 301 5.7
protein complex format 6 24 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine