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Target Snapshot

CHEMBL2096661 Target Snapshot

Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 · PROTEIN COMPLEX · Homo sapiens

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588Compounds
83Assays
2Approved Drugs
683.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P20701. Use UniProt P20701 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P20701 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 as ChEMBL target CHEMBL2096661, mapped to UniProt P20701. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2096661
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P20701
Integrin alpha-L
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 is the right protein anchor across sources, using UniProt P20701 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred NameIntercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP20701
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelIntegrin alpha-L
UniProt AccessionP20701
Component TypeProtein
Sequence Length1170 aa

Integrin alpha-L

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2, mapped to UniProt P20701. ChEMBL maps the protein component as Integrin alpha-L. Sequence length is 1170 aa.

Mapped IDP20701
Review nameIntercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC50632.0
EC502.0
KD49.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL336789 10.0 IC50 0.1 Preclinical
CHEMBL488318 9.46 IC50 0.35 Preclinical
CHEMBL452882 9.4 IC50 0.4 Preclinical
CHEMBL337562 9.3 IC50 0.5 Preclinical
CHEMBL472841 9.3 IC50 0.5 Preclinical
CHEMBL520731 9.3 IC50 0.5 Preclinical
CHEMBL502756 9.22 IC50 0.6 Preclinical
CHEMBL485857 9.05 IC50 0.9 Preclinical
CHEMBL444773 9.03 IC50 0.94 Preclinical
CHEMBL1644132 8.92 IC50 1.2 Preclinical
Distribution

pChEMBL Value Distribution

40
5.0
47
5.5
96
6.0
103
6.5
102
7.0
58
7.5
54
8.0
17
8.5
8
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LIFITEGRAST
CHEMBL2048028
Approved 2016
Properties Compare Identifier
Assay Landscape

Assay Landscape

83
Total Assays
413
Tested Compounds
2
Assay Types
Binding — 49 assays, 413 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 28 75 7.0
protein complex format 21 338 6.5
Functional — 34 assays, 118 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 26 77 7.1
organism-based format 5 0 —
assay format 3 41 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine