Pyruvate dehydrogenase kinase · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q63065. Use UniProt Q63065 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q63065 as the stable identity anchor, then attach disease evidence before program review.
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
Review this target as Pyruvate dehydrogenase kinase, mapped to UniProt Q63065. ChEMBL maps the protein component as [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial. Sequence length is 434 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Pyruvate dehydrogenase kinase as ChEMBL target CHEMBL2096663, mapped to UniProt Q63065. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Pyruvate dehydrogenase kinase |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | Q63065 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial |
| UniProt Accession | Q63065 |
| Component Type | Protein |
| Sequence Length | 434 aa |
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
Review this target as Pyruvate dehydrogenase kinase, mapped to UniProt Q63065. ChEMBL maps the protein component as [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial. Sequence length is 434 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL83273 | 8.48 | IC50 | 3.3 | Preclinical |
| CHEMBL311125 | 8.35 | IC50 | 4.5 | Preclinical |
| CHEMBL3349325 | 8.04 | IC50 | 9.1 | Preclinical |
| CHEMBL443012 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL313878 | 7.84 | IC50 | 14.3 | Preclinical |
| CHEMBL316388 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL81574 | 7.72 | IC50 | 19.0 | Preclinical |
| CHEMBL310879 | 7.7 | IC50 | 19.8 | Preclinical |
| CHEMBL84231 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL84271 | 7.6 | IC50 | 25.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 27 | 0 | — |
| tissue-based format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 2 | 68 | 6.0 |