Steroid 5-alpha-reductase · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P24008. Use UniProt P24008 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P24008 as the stable identity anchor, then attach disease evidence before program review.
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Review this target as Steroid 5-alpha-reductase, mapped to UniProt P24008. ChEMBL maps the protein component as 3-oxo-5-alpha-steroid 4-dehydrogenase 1. Sequence length is 259 aa.
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This review treats Steroid 5-alpha-reductase as ChEMBL target CHEMBL2096664, mapped to UniProt P24008. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Steroid 5-alpha-reductase |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P24008 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
| UniProt Accession | P24008 |
| Component Type | Protein |
| Sequence Length | 259 aa |
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Review this target as Steroid 5-alpha-reductase, mapped to UniProt P24008. ChEMBL maps the protein component as 3-oxo-5-alpha-steroid 4-dehydrogenase 1. Sequence length is 259 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL133338 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL3349118 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL3349105 | 9.68 | IC50 | 0.21 | Preclinical |
| CHEMBL3349170 | 9.25 | IC50 | 0.56 | Preclinical |
| CHEMBL25193 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3349075 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL289613 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL39419 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL1790294 | 8.77 | IC50 | 1.7 | Preclinical |
| CHEMBL1790294 | 8.77 | Ki | 1.7 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 26 | 125 | 7.0 |
| tissue-based format | 10 | 114 | 7.2 |
| assay format | 3 | 7 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 0 | — |