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Target Snapshot

CHEMBL2096904 Target Snapshot

Serotonin (5-HT) receptor · PROTEIN FAMILY · Homo sapiens

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50Compounds
35Assays
2Approved Drugs
25.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Serotonin (5-HT) receptor shows approved-linked disease relevance led by Nausea and vomiting. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P30939. Start with Nausea and vomiting, then reuse UniProt P30939 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with Nausea and vomiting, then reuse UniProt P30939 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
Nausea and vomiting

Serotonin (5-HT) receptor shows approved-linked disease relevance led by Nausea and vomiting. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with Nausea and vomiting because it currently carries approved-linked support. Linked drugs include AMISULPRIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serotonin (5-HT) receptor as ChEMBL target CHEMBL2096904, mapped to UniProt P30939. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serotonin (5-HT) receptor
PROTEIN FAMILY · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2096904
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P30939
5-hydroxytryptamine receptor 1F
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serotonin (5-HT) receptor is the right protein anchor across sources, using UniProt P30939 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why Nausea and vomiting is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameSerotonin (5-HT) receptor
Target TypePROTEIN FAMILY
OrganismHomo sapiens
UniProtP30939
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label5-hydroxytryptamine receptor 1F
UniProt AccessionP30939
Component TypeProtein
Sequence Length366 aa

5-hydroxytryptamine receptor 1F

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Serotonin (5-HT) receptor, mapped to UniProt P30939. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 1F. Sequence length is 366 aa.

Mapped IDP30939
Review nameSerotonin (5-HT) receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Serotonin (5-HT) receptor shows approved-linked disease relevance led by Nausea and vomiting. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
Nausea and vomiting
1 linked drug · 1 direct · 1 efficacy
Linked drugAMISULPRIDE
Approved-linked Approved
post operative nausea and vomiting
1 linked drug · 1 direct · 1 efficacy
Linked drugAMISULPRIDE
Approved-linked Approved
psychosis
1 linked drug · 1 direct · 1 efficacy
Linked drugAMISULPRIDE
Late clinical Phase III
anxiety
1 linked drug · 1 direct · 1 efficacy
Linked drugAMISULPRIDE
Late clinical Phase III
Dementia
1 linked drug · 1 direct · 1 efficacy
Linked drugAMISULPRIDE
Late clinical Phase III
depressive disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugAMISULPRIDE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with Nausea and vomiting because it currently carries approved-linked support. Linked drugs include AMISULPRIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseNausea and vomiting
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5017.0
KI3.0
KD5.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL323208 9.8 Kd 0.1585 Preclinical
CHEMBL11 8.96 IC50 1.1 Approved
CHEMBL11 8.96 Ki 1.1 Approved
CHEMBL7257 7.1 Kd 79.43 Clinical
CHEMBL31783 6.0 IC50 1000.0 Preclinical
CHEMBL2424668 5.9 Ki 1270.0 Preclinical
CHEMBL352315 5.65 IC50 2240.0 Preclinical
CHEMBL417480 4.39 IC50 40800.0 Preclinical
CHEMBL283686 4.39 IC50 40700.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
2
5.5
1
6.0
0
6.5
1
7.0
0
7.5
0
8.0
2
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

IMIPRAMINE
CHEMBL11
Approved 1959
Properties Compare Identifier
Assay Landscape

Assay Landscape

35
Total Assays
10
Tested Compounds
3
Assay Types
Binding — 17 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 16 10 6.8
tissue-based format 1 0 —
Functional — 17 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 8 0 —
assay format 7 5 —
tissue-based format 2 0 —
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine