Acetylcholine receptor · PROTEIN COMPLEX · Torpedo californica
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As of 2026-09-13Protein identity stays anchored to UniProt P02710. Use UniProt P02710 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P02710 as the stable identity anchor, then attach disease evidence before program review.
Acetylcholine receptor subunit alpha
Review this target as Acetylcholine receptor, mapped to UniProt P02710. ChEMBL maps the protein component as Acetylcholine receptor subunit alpha. Sequence length is 461 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Acetylcholine receptor as ChEMBL target CHEMBL2096975, mapped to UniProt P02710. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Acetylcholine receptor |
| Target Type | PROTEIN COMPLEX |
| Organism | Torpedo californica |
| UniProt | P02710 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Acetylcholine receptor subunit alpha |
| UniProt Accession | P02710 |
| Component Type | Protein |
| Sequence Length | 461 aa |
Acetylcholine receptor subunit alpha
Review this target as Acetylcholine receptor, mapped to UniProt P02710. ChEMBL maps the protein component as Acetylcholine receptor subunit alpha. Sequence length is 461 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL149667 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL25619 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL3 | 9.0 | IC50 | 1.0 | Approved |
| CHEMBL6623 | 8.57 | Ki | 2.7 | Preclinical |
| CHEMBL136284 | 7.75 | Ki | 18.0 | Preclinical |
| CHEMBL136284 | 7.75 | Kd | 18.0 | Preclinical |
| CHEMBL6200 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL6623 | 6.7 | EC50 | 200.0 | Preclinical |
| CHEMBL138569 | 6.64 | Kd | 230.0 | Preclinical |
| CHEMBL497939 | 6.6 | Ki | 250.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 10 | 20 | 6.2 |
| assay format | 4 | 9 | 7.8 |
| tissue-based format | 4 | 19 | 5.1 |
| cell membrane format | 2 | 0 | — |
| cell-based format | 1 | 1 | 4.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| cell-based format | 1 | 1 | 4.4 |
| tissue-based format | 1 | 0 | — |