Thioredoxin reductase · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q16881. Use UniProt Q16881 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q16881 as the stable identity anchor, then attach disease evidence before program review.
Thioredoxin reductase 1, cytoplasmic
Review this target as Thioredoxin reductase, mapped to UniProt Q16881. ChEMBL maps the protein component as Thioredoxin reductase 1, cytoplasmic. Sequence length is 649 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thioredoxin reductase as ChEMBL target CHEMBL2096978, mapped to UniProt Q16881. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Thioredoxin reductase is the right protein anchor across sources, using UniProt Q16881 as the stable mapping.
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| Preferred Name | Thioredoxin reductase |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | Q16881 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thioredoxin reductase 1, cytoplasmic |
| UniProt Accession | Q16881 |
| Component Type | Protein |
| Sequence Length | 649 aa |
Thioredoxin reductase 1, cytoplasmic
Review this target as Thioredoxin reductase, mapped to UniProt Q16881. ChEMBL maps the protein component as Thioredoxin reductase 1, cytoplasmic. Sequence length is 649 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL120147 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL217200 | 6.58 | IC50 | 260.0 | Preclinical |
| CHEMBL3814977 | 6.55 | Ki | 280.0 | Preclinical |
| CHEMBL88230 | 6.46 | IC50 | 350.0 | Preclinical |
| CHEMBL412348 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL413290 | 5.92 | IC50 | 1200.0 | Preclinical |
| CHEMBL4451948 | 5.91 | IC50 | 1220.0 | Preclinical |
| CHEMBL3290761 | 5.85 | IC50 | 1400.0 | Preclinical |
| CHEMBL385299 | 5.8 | IC50 | 1600.0 | Preclinical |
| CHEMBL440625 | 5.8 | IC50 | 1600.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 37 | 11 | 5.4 |
| protein format | 34 | 34 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 15 | 16 | 5.0 |