Geranylgeranyl transferase type I · PROTEIN COMPLEX · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P29702. Use UniProt P29702 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P29702 as the stable identity anchor, then attach disease evidence before program review.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Geranylgeranyl transferase type I, mapped to UniProt P29702. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 375 aa.
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This review treats Geranylgeranyl transferase type I as ChEMBL target CHEMBL2096987, mapped to UniProt P29702. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Geranylgeranyl transferase type I |
| Target Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
| UniProt | P29702 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| UniProt Accession | P29702 |
| Component Type | Protein |
| Sequence Length | 375 aa |
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Geranylgeranyl transferase type I, mapped to UniProt P29702. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 375 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL62387 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL158553 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL2371368 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL128309 | 8.57 | IC50 | 2.7 | Preclinical |
| CHEMBL129140 | 8.21 | IC50 | 6.2 | Preclinical |
| CHEMBL128967 | 8.17 | IC50 | 6.8 | Preclinical |
| CHEMBL132155 | 8.09 | IC50 | 8.2 | Preclinical |
| CHEMBL129603 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL1790750 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL305536 | 7.96 | IC50 | 11.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 27 | 136 | 6.1 |
| assay format | 3 | 10 | 5.5 |