Protein farnesyl/geranylgeranyl transferase · PROTEIN COMPLEX GROUP · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P49354. Use UniProt P49354 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49354 as the stable identity anchor, then attach disease evidence before program review.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Protein farnesyl/geranylgeranyl transferase, mapped to UniProt P49354. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 379 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein farnesyl/geranylgeranyl transferase as ChEMBL target CHEMBL2096991, mapped to UniProt P49354. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Protein farnesyl/geranylgeranyl transferase |
| Target Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
| UniProt | P49354 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| UniProt Accession | P49354 |
| Component Type | Protein |
| Sequence Length | 379 aa |
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Protein farnesyl/geranylgeranyl transferase, mapped to UniProt P49354. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 379 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL279433 | 7.04 | EC50 | 92.0 | Preclinical |
| CHEMBL318626 | 7.0 | EC50 | 100.0 | Preclinical |
| CHEMBL316673 | 6.68 | EC50 | 207.0 | Preclinical |
| CHEMBL450336 | 6.66 | EC50 | 220.0 | Preclinical |
| CHEMBL439047 | 6.64 | EC50 | 230.0 | Preclinical |
| CHEMBL99901 | 6.5 | EC50 | 320.0 | Preclinical |
| CHEMBL294888 | 6.47 | EC50 | 340.0 | Preclinical |
| CHEMBL322435 | 5.89 | EC50 | 1290.0 | Preclinical |
| CHEMBL2111612 | 5.72 | EC50 | 1900.0 | Preclinical |
| CHEMBL323302 | 5.43 | EC50 | 3730.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 15 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 11 | 6.3 |