Neuronal acetylcholine receptor; alpha2/beta2 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P17787. Use UniProt P17787 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P17787 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit beta-2
Review this target as Neuronal acetylcholine receptor; alpha2/beta2, mapped to UniProt P17787. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-2. Sequence length is 502 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor; alpha2/beta2 as ChEMBL target CHEMBL2109236, mapped to UniProt P17787. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Neuronal acetylcholine receptor; alpha2/beta2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P17787 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit beta-2 |
| UniProt Accession | P17787 |
| Component Type | Protein |
| Sequence Length | 502 aa |
Neuronal acetylcholine receptor subunit beta-2
Review this target as Neuronal acetylcholine receptor; alpha2/beta2, mapped to UniProt P17787. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-2. Sequence length is 502 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2024096 | 10.06 | Ki | 0.087 | Preclinical |
| CHEMBL6007325 | 10.06 | Ki | 0.087 | Preclinical |
| CHEMBL1076903 | 9.32 | Ki | 0.48 | Approved |
| CHEMBL429557 | 9.12 | IC50 | 0.75 | Preclinical |
| CHEMBL411146 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL2323570 | 8.28 | Ki | 5.3 | Preclinical |
| CHEMBL5896203 | 8.28 | Ki | 5.3 | Preclinical |
| CHEMBL3 | 8.26 | Ki | 5.5 | Approved |
| CHEMBL2323572 | 8.07 | Ki | 8.6 | Preclinical |
| CHEMBL5873522 | 8.07 | Ki | 8.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 6 | 5 | 7.7 |
| cell-based format | 4 | 0 | — |
| assay format | 2 | 19 | 7.7 |