GABA A receptor alpha-2/beta-2/gamma-2 · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P18508. Use UniProt P18508 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18508 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit gamma-2
Review this target as GABA A receptor alpha-2/beta-2/gamma-2, mapped to UniProt P18508. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit gamma-2. Sequence length is 466 aa.
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This review treats GABA A receptor alpha-2/beta-2/gamma-2 as ChEMBL target CHEMBL2111327, mapped to UniProt P18508. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether GABA A receptor alpha-2/beta-2/gamma-2 is the right protein anchor across sources, using UniProt P18508 as the stable mapping.
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| Preferred Name | GABA A receptor alpha-2/beta-2/gamma-2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | P18508 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit gamma-2 |
| UniProt Accession | P18508 |
| Component Type | Protein |
| Sequence Length | 466 aa |
Gamma-aminobutyric acid receptor subunit gamma-2
Review this target as GABA A receptor alpha-2/beta-2/gamma-2, mapped to UniProt P18508. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit gamma-2. Sequence length is 466 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL372281 | 7.86 | Ki | 13.9 | Preclinical |
| CHEMBL192554 | 7.84 | Ki | 14.3 | Preclinical |
| CHEMBL191088 | 7.75 | Ki | 18.0 | Preclinical |
| CHEMBL502159 | 7.75 | Ki | 18.0 | Preclinical |
| CHEMBL522061 | 7.72 | Ki | 19.0 | Preclinical |
| CHEMBL12 | 7.7 | Ki | 20.0 | Approved |
| CHEMBL192555 | 7.56 | Ki | 27.6 | Preclinical |
| CHEMBL376508 | 7.09 | Ki | 81.0 | Preclinical |
| CHEMBL452728 | 6.92 | Ki | 120.0 | Preclinical |
| CHEMBL911 | 6.81 | Ki | 156.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 24 | 6.8 |
| protein complex format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 1 | — |