Serotonin 3 receptor (5HT3) · PROTEIN FAMILY · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q9JHJ5. Use UniProt Q9JHJ5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9JHJ5 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 3B
Review this target as Serotonin 3 receptor (5HT3), mapped to UniProt Q9JHJ5. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 3B. Sequence length is 437 aa.
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This review treats Serotonin 3 receptor (5HT3) as ChEMBL target CHEMBL2111333, mapped to UniProt Q9JHJ5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serotonin 3 receptor (5HT3) |
| Target Type | PROTEIN FAMILY |
| Organism | Mus musculus |
| UniProt | Q9JHJ5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 3B |
| UniProt Accession | Q9JHJ5 |
| Component Type | Protein |
| Sequence Length | 437 aa |
5-hydroxytryptamine receptor 3B
Review this target as Serotonin 3 receptor (5HT3), mapped to UniProt Q9JHJ5. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 3B. Sequence length is 437 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL18041 | 8.88 | Ki | 1.32 | Clinical |
| CHEMBL56564 | 8.42 | Ki | 3.8 | Clinical |
| CHEMBL18772 | 8.06 | Ki | 8.67 | Clinical |
| CHEMBL27846 | 8.02 | Ki | 9.5 | Preclinical |
| CHEMBL46 | 7.92 | Ki | 12.0 | Approved |
| CHEMBL86 | 6.7 | Ki | 200.0 | Approved |
| CHEMBL6437 | 6.6 | Ki | 252.0 | Approved |
| CHEMBL39 | 6.44 | Ki | 361.0 | Clinical |
| CHEMBL266591 | 5.84 | Ki | 1430.0 | Preclinical |
| CHEMBL422453 | 5.45 | IC50 | 3590.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 12 | 2 | 7.4 |
| cell-based format | 8 | 18 | 5.8 |
| assay format | 3 | 1 | 4.7 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 6 | 0 | — |