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Target Snapshot

CHEMBL2111338 Target Snapshot

Alpha-2 adrenergic receptor · PROTEIN FAMILY · Mus musculus

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54Compounds
24Assays
2Approved Drugs
21.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P30545. Use UniProt P30545 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P30545 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Alpha-2 adrenergic receptor as ChEMBL target CHEMBL2111338, mapped to UniProt P30545. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Alpha-2 adrenergic receptor
PROTEIN FAMILY · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL2111338
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P30545
Alpha-2B adrenergic receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Alpha-2 adrenergic receptor is the right protein anchor across sources, using UniProt P30545 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAlpha-2 adrenergic receptor
Target TypePROTEIN FAMILY
OrganismMus musculus
UniProtP30545
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAlpha-2B adrenergic receptor
UniProt AccessionP30545
Component TypeProtein
Sequence Length453 aa

Alpha-2B adrenergic receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Alpha-2 adrenergic receptor, mapped to UniProt P30545. ChEMBL maps the protein component as Alpha-2B adrenergic receptor. Sequence length is 453 aa.

Mapped IDP30545
Review nameAlpha-2 adrenergic receptor
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Approved
2
Phase III
Assay Mix

Activity Type Distribution

KI12.0
KD9.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL15245 9.22 Ki 0.6 Clinical
CHEMBL10347 9.1 Ki 0.8 Preclinical
CHEMBL554430 8.63 Kd 2.344 Preclinical
CHEMBL542760 8.35 Kd 4.467 Preclinical
CHEMBL539313 8.32 Kd 4.786 Preclinical
CHEMBL541870 8.22 Kd 6.026 Preclinical
CHEMBL15245 7.98 Kd 10.47 Clinical
CHEMBL543467 7.98 Kd 10.47 Preclinical
CHEMBL540844 7.97 Kd 10.72 Preclinical
CHEMBL2 7.89 Ki 13.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
0
6.0
2
6.5
4
7.0
6
7.5
4
8.0
1
8.5
3
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

OXYMETAZOLINE
CHEMBL762
Approved 1986
Properties Compare Identifier
PRAZOSIN
CHEMBL2
Approved 1976
Properties Compare Identifier
Assay Landscape

Assay Landscape

24
Total Assays
9
Tested Compounds
2
Assay Types
Functional — 12 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 11 9 8.1
assay format 1 0 —
Binding — 12 assays, 8 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 9 4 7.4
cell-based format 3 4 8.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine