Dopamine D1 and D2 receptor · SELECTIVITY GROUP · Homo sapiens
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As of 2026-09-14Dopamine D1 and D2 receptor shows approved-linked disease relevance led by major depressive disorder. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P14416. Start with major depressive disorder, then reuse UniProt P14416 as the stable protein anchor across project notes and exports.
Start with major depressive disorder, then reuse UniProt P14416 as the stable protein anchor across project notes and exports.
Dopamine D1 and D2 receptor shows approved-linked disease relevance led by major depressive disorder. 2 linked drugs remain visible in the same block.
Start review with major depressive disorder because it currently carries approved-linked support. Linked drugs include AMINEPTINE, MINAPRINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyD(2) dopamine receptor
Review this target as Dopamine D1 and D2 receptor, mapped to UniProt P14416. ChEMBL maps the protein component as D(2) dopamine receptor. Sequence length is 443 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dopamine D1 and D2 receptor as ChEMBL target CHEMBL2111341, mapped to UniProt P14416. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Dopamine D1 and D2 receptor is the right protein anchor across sources, using UniProt P14416 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why major depressive disorder is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Dopamine D1 and D2 receptor |
| Target Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
| UniProt | P14416 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | D(2) dopamine receptor |
| UniProt Accession | P14416 |
| Component Type | Protein |
| Sequence Length | 443 aa |
D(2) dopamine receptor
Review this target as Dopamine D1 and D2 receptor, mapped to UniProt P14416. ChEMBL maps the protein component as D(2) dopamine receptor. Sequence length is 443 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Dopamine D1 and D2 receptor shows approved-linked disease relevance led by major depressive disorder.
Start review with major depressive disorder because it currently carries approved-linked support. Linked drugs include AMINEPTINE, MINAPRINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 13 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |