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Target Snapshot

CHEMBL2111354 Target Snapshot

Tubulin · PROTEIN FAMILY · Sus scrofa

863Compounds
330Assays
9Approved Drugs
694.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P02554. Use UniProt P02554 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P02554 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Tubulin as ChEMBL target CHEMBL2111354, mapped to UniProt P02554. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Tubulin
PROTEIN FAMILY · Sus scrofa
As of 2026-09-14
ChEMBL target ID
CHEMBL2111354
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P02554
Tubulin beta chain
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Tubulin is the right protein anchor across sources, using UniProt P02554 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTubulin beta chain
UniProt AccessionP02554
Component TypeProtein
Sequence Length445 aa

Tubulin beta chain

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Tubulin, mapped to UniProt P02554. ChEMBL maps the protein component as Tubulin beta chain. Sequence length is 445 aa.

Mapped IDP02554
Review nameTubulin
OrganismSus scrofa
Clinical Profile

Clinical Phase Distribution

9
Approved
2
Phase III
3
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50633.0
KI34.0
EC5010.0
KD17.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2181004 10.34 Ki 0.04603 Preclinical
CHEMBL2181003 10.23 Ki 0.05848 Preclinical
CHEMBL2181002 10.2 Ki 0.06368 Preclinical
CHEMBL2181009 9.91 Ki 0.1219 Preclinical
CHEMBL2181006 9.9 Ki 0.1268 Preclinical
CHEMBL2181001 9.88 Ki 0.1312 Preclinical
CHEMBL2181000 9.85 Ki 0.1426 Preclinical
CHEMBL2181008 9.74 Ki 0.1832 Preclinical
CHEMBL2180999 9.7 Ki 0.1982 Preclinical
CHEMBL2181007 9.55 Ki 0.2799 Preclinical
Distribution

pChEMBL Value Distribution

124
5.0
147
5.5
90
6.0
13
6.5
0
7.0
0
7.5
3
8.0
3
8.5
1
9.0
7
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
PODOFILOX
CHEMBL61
Approved 1990
VINBLASTINE SULFATE
CHEMBL378544
Approved 1965
VINBLASTINE
CHEMBL159
Approved 1965
COLCHICINE
CHEMBL107
Approved 1961
Assay Landscape

Assay Landscape

330
Total Assays
335
Tested Compounds
2
Assay Types
Binding — 321 assays, 335 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 188 218 5.6
protein format 112 79 5.6
tissue-based format 20 38 6.5
cell-based format 1 0
Functional — 9 assays, 31 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 9 31 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine