Prostaglandin G/H synthase (cyclooxygenase) · PROTEIN FAMILY · Ovis aries
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As of 2026-09-14Protein identity stays anchored to UniProt P05979. Use UniProt P05979 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P05979 as the stable identity anchor, then attach disease evidence before program review.
Prostaglandin G/H synthase 1
Review this target as Prostaglandin G/H synthase (cyclooxygenase), mapped to UniProt P05979. ChEMBL maps the protein component as Prostaglandin G/H synthase 1. Sequence length is 600 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prostaglandin G/H synthase (cyclooxygenase) as ChEMBL target CHEMBL2111358, mapped to UniProt P05979. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Prostaglandin G/H synthase (cyclooxygenase) is the right protein anchor across sources, using UniProt P05979 as the stable mapping.
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| Preferred Name | Prostaglandin G/H synthase (cyclooxygenase) |
| Target Type | PROTEIN FAMILY |
| Organism | Ovis aries |
| UniProt | P05979 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prostaglandin G/H synthase 1 |
| UniProt Accession | P05979 |
| Component Type | Protein |
| Sequence Length | 600 aa |
Prostaglandin G/H synthase 1
Review this target as Prostaglandin G/H synthase (cyclooxygenase), mapped to UniProt P05979. ChEMBL maps the protein component as Prostaglandin G/H synthase 1. Sequence length is 600 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL284705 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL33378 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL6 | 6.82 | IC50 | 150.0 | Approved |
| CHEMBL33987 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL274642 | 5.89 | IC50 | 1300.0 | Preclinical |
| CHEMBL34003 | 5.89 | IC50 | 1300.0 | Preclinical |
| CHEMBL285188 | 5.85 | IC50 | 1400.0 | Preclinical |
| CHEMBL32961 | 5.85 | IC50 | 1400.0 | Preclinical |
| CHEMBL32990 | 5.75 | IC50 | 1800.0 | Preclinical |
| CHEMBL286802 | 5.16 | IC50 | 7000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 9 | 0 | — |
| tissue-based format | 6 | 19 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 0 | — |