Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O15379. Use UniProt O15379 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15379 as the stable identity anchor, then attach disease evidence before program review.
Histone deacetylase 3
Review this target as Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2), mapped to UniProt O15379. ChEMBL maps the protein component as Histone deacetylase 3. Sequence length is 428 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) as ChEMBL target CHEMBL2111363, mapped to UniProt O15379. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) is the right protein anchor across sources, using UniProt O15379 as the stable mapping.
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| Preferred Name | Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | O15379 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone deacetylase 3 |
| UniProt Accession | O15379 |
| Component Type | Protein |
| Sequence Length | 428 aa |
Histone deacetylase 3
Review this target as Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2), mapped to UniProt O15379. ChEMBL maps the protein component as Histone deacetylase 3. Sequence length is 428 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4444219 | 9.76 | IC50 | 0.1726 | Preclinical |
| CHEMBL99 | 9.59 | Ki | 0.26 | Preclinical |
| CHEMBL5083249 | 9.42 | IC50 | 0.38 | Preclinical |
| CHEMBL5078985 | 9.37 | IC50 | 0.43 | Preclinical |
| CHEMBL5087431 | 9.26 | IC50 | 0.55 | Preclinical |
| CHEMBL4744689 | 9.18 | IC50 | 0.66 | Preclinical |
| CHEMBL3593247 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL5532146 | 9.14 | IC50 | 0.72 | Preclinical |
| CHEMBL3970532 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5565699 | 8.97 | IC50 | 1.08 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 75 | 263 | 6.9 |
| protein complex format | 63 | 141 | 6.9 |
| assay format | 14 | 22 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 8 | 35 | 6.3 |
| assay format | 2 | 2 | 8.2 |
| protein complex format | 1 | 3 | 5.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 5.9 |