CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9UBU7. Use UniProt Q9UBU7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UBU7 as the stable identity anchor, then attach disease evidence before program review.
Protein DBF4 homolog A
Review this target as CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase), mapped to UniProt Q9UBU7. ChEMBL maps the protein component as Protein DBF4 homolog A. Sequence length is 674 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) as ChEMBL target CHEMBL2111377, mapped to UniProt Q9UBU7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q9UBU7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein DBF4 homolog A |
| UniProt Accession | Q9UBU7 |
| Component Type | Protein |
| Sequence Length | 674 aa |
Protein DBF4 homolog A
Review this target as CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase), mapped to UniProt Q9UBU7. ChEMBL maps the protein component as Protein DBF4 homolog A. Sequence length is 674 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1958411 | 10.05 | Ki | 0.09 | Preclinical |
| CHEMBL1958417 | 9.96 | Ki | 0.11 | Preclinical |
| CHEMBL1958412 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL1958416 | 9.85 | Ki | 0.14 | Preclinical |
| CHEMBL4436649 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL4462898 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL1958414 | 9.74 | Ki | 0.18 | Preclinical |
| CHEMBL1958415 | 9.74 | Ki | 0.18 | Preclinical |
| CHEMBL1958419 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL1958420 | 9.7 | Ki | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 68 | 97 | 6.9 |
| assay format | 22 | 115 | 8.2 |
| cell-based format | 8 | 59 | 6.3 |