Protein farnesyltransferase (PFT) · PROTEIN COMPLEX · Plasmodium falciparum
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As of 2026-09-14Protein identity stays anchored to UniProt Q5EI73. Use UniProt Q5EI73 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q5EI73 as the stable identity anchor, then attach disease evidence before program review.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Protein farnesyltransferase (PFT), mapped to UniProt Q5EI73. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 521 aa.
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This review treats Protein farnesyltransferase (PFT) as ChEMBL target CHEMBL2111381, mapped to UniProt Q5EI73. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Protein farnesyltransferase (PFT) |
| Target Type | PROTEIN COMPLEX |
| Organism | Plasmodium falciparum |
| UniProt | Q5EI73 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| UniProt Accession | Q5EI73 |
| Component Type | Protein |
| Sequence Length | 521 aa |
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Protein farnesyltransferase (PFT), mapped to UniProt Q5EI73. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 521 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL193034 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL215769 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL181102 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL182888 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL214610 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL365742 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL183536 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL370298 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL194447 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL373337 | 8.85 | IC50 | 1.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 5 | 35 | 8.1 |