Serotonin receptor 2a and 2c (5HT2A and 5HT2C) · SELECTIVITY GROUP · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P08909. Use UniProt P08909 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08909 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 2C
Review this target as Serotonin receptor 2a and 2c (5HT2A and 5HT2C), mapped to UniProt P08909. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 2C. Sequence length is 460 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serotonin receptor 2a and 2c (5HT2A and 5HT2C) as ChEMBL target CHEMBL2111383, mapped to UniProt P08909. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serotonin receptor 2a and 2c (5HT2A and 5HT2C) |
| Target Type | SELECTIVITY GROUP |
| Organism | Rattus norvegicus |
| UniProt | P08909 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 2C |
| UniProt Accession | P08909 |
| Component Type | Protein |
| Sequence Length | 460 aa |
5-hydroxytryptamine receptor 2C
Review this target as Serotonin receptor 2a and 2c (5HT2A and 5HT2C), mapped to UniProt P08909. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 2C. Sequence length is 460 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL69700 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL267930 | 9.3 | Ki | 0.5 | Clinical |
| CHEMBL6616 | 9.15 | Ki | 0.7 | Preclinical |
| CHEMBL136354 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL51 | 8.92 | Ki | 1.2 | Clinical |
| CHEMBL51 | 8.86 | Kd | 1.37 | Clinical |
| CHEMBL6620 | 8.82 | Ki | 1.5 | Preclinical |
| CHEMBL338297 | 8.72 | Ki | 1.9 | Preclinical |
| CHEMBL18786 | 8.42 | Ki | 3.8 | Clinical |
| CHEMBL39 | 8.21 | Ki | 6.1 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 10 | 4 | 8.2 |
| tissue-based format | 7 | 6 | 8.4 |