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Target Snapshot

CHEMBL2111389 Target Snapshot

CDK9/cyclin T1 · PROTEIN COMPLEX · Homo sapiens

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3,966Compounds
548Assays
5Approved Drugs
3,530.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O60563. Use UniProt O60563 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O60563 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CDK9/cyclin T1 as ChEMBL target CHEMBL2111389, mapped to UniProt O60563. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CDK9/cyclin T1
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2111389
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O60563
Cyclin-T1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CDK9/cyclin T1 is the right protein anchor across sources, using UniProt O60563 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCDK9/cyclin T1
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtO60563
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCyclin-T1
UniProt AccessionO60563
Component TypeProtein
Sequence Length726 aa

Cyclin-T1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CDK9/cyclin T1, mapped to UniProt O60563. ChEMBL maps the protein component as Cyclin-T1. Sequence length is 726 aa.

Mapped IDO60563
Review nameCDK9/cyclin T1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Approved
3
Phase III
16
Phase II
12
Phase I
Assay Mix

Activity Type Distribution

IC503,269.0
KI245.0
KD16.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4462530 10.05 Kd 0.0894 Clinical
CHEMBL4754081 9.91 Kd 0.123 Preclinical
CHEMBL4754399 9.53 Kd 0.295 Preclinical
CHEMBL3932121 9.4 Ki 0.4 Preclinical
CHEMBL4217448 9.4 IC50 0.4 Preclinical
CHEMBL5896735 9.39 IC50 0.406 Preclinical
CHEMBL5833416 9.38 IC50 0.416 Preclinical
CHEMBL5968336 9.34 IC50 0.455 Preclinical
CHEMBL5882812 9.32 IC50 0.477 Preclinical
CHEMBL6064411 9.32 IC50 0.48 Preclinical
Distribution

pChEMBL Value Distribution

126
5.0
159
5.5
263
6.0
713
6.5
801
7.0
404
7.5
256
8.0
137
8.5
39
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

ABEMACICLIB
CHEMBL3301610
Approved 2017
Properties Compare Identifier
RIBOCICLIB
CHEMBL3545110
Approved 2017
Properties Compare Identifier
PALBOCICLIB
CHEMBL189963
Approved 2015
Properties Compare Identifier
Assay Landscape

Assay Landscape

548
Total Assays
2,794
Tested Compounds
2
Assay Types
Binding — 545 assays, 2,794 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 312 2,375 7.1
cell-based format 199 297 7.1
assay format 32 119 6.9
single protein format 2 3 7.8
ADME — 3 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 1 6.3
protein complex format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine