Farnesyltransferase · PROTEIN COMPLEX · Saccharomyces cerevisiae S288c
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As of 2026-09-14Protein identity stays anchored to UniProt P29703. Use UniProt P29703 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P29703 as the stable identity anchor, then attach disease evidence before program review.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Farnesyltransferase, mapped to UniProt P29703. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 316 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Farnesyltransferase as ChEMBL target CHEMBL2111393, mapped to UniProt P29703. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Farnesyltransferase |
| Target Type | PROTEIN COMPLEX |
| Organism | Saccharomyces cerevisiae S288c |
| UniProt | P29703 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| UniProt Accession | P29703 |
| Component Type | Protein |
| Sequence Length | 316 aa |
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Farnesyltransferase, mapped to UniProt P29703. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 316 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL108161 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL274122 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL321981 | 8.27 | IC50 | 5.4 | Preclinical |
| CHEMBL322854 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL104460 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL67122 | 7.46 | IC50 | 35.0 | Preclinical |
| CHEMBL431632 | 7.44 | IC50 | 36.0 | Preclinical |
| CHEMBL69330 | 7.12 | Kd | 75.0 | Preclinical |
| CHEMBL95848 | 7.12 | IC50 | 76.0 | Preclinical |
| CHEMBL99867 | 7.11 | IC50 | 77.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 11 | 57 | 6.2 |