Serotonin receptor 2a and 2b (5HT2A and 5HT2B) · SELECTIVITY GROUP · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P30994. Use UniProt P30994 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P30994 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 2B
Review this target as Serotonin receptor 2a and 2b (5HT2A and 5HT2B), mapped to UniProt P30994. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 2B. Sequence length is 479 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serotonin receptor 2a and 2b (5HT2A and 5HT2B) as ChEMBL target CHEMBL2111398, mapped to UniProt P30994. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serotonin receptor 2a and 2b (5HT2A and 5HT2B) |
| Target Type | SELECTIVITY GROUP |
| Organism | Rattus norvegicus |
| UniProt | P30994 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 2B |
| UniProt Accession | P30994 |
| Component Type | Protein |
| Sequence Length | 479 aa |
5-hydroxytryptamine receptor 2B
Review this target as Serotonin receptor 2a and 2b (5HT2A and 5HT2B), mapped to UniProt P30994. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 2B. Sequence length is 479 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL66335 | 8.58 | Ki | 2.63 | Preclinical |
| CHEMBL263881 | 8.2 | Ki | 6.31 | Clinical |
| CHEMBL302997 | 8.11 | Ki | 7.76 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 3 | 0 | — |
| assay format | 2 | 3 | 8.3 |