5-lipoxygenase/FLAP · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P09917. Use UniProt P09917 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P09917 as the stable identity anchor, then attach disease evidence before program review.
Polyunsaturated fatty acid 5-lipoxygenase
Review this target as 5-lipoxygenase/FLAP, mapped to UniProt P09917. ChEMBL maps the protein component as Polyunsaturated fatty acid 5-lipoxygenase. Sequence length is 674 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-lipoxygenase/FLAP as ChEMBL target CHEMBL2111402, mapped to UniProt P09917. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 5-lipoxygenase/FLAP is the right protein anchor across sources, using UniProt P09917 as the stable mapping.
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| Preferred Name | 5-lipoxygenase/FLAP |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P09917 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Polyunsaturated fatty acid 5-lipoxygenase |
| UniProt Accession | P09917 |
| Component Type | Protein |
| Sequence Length | 674 aa |
Polyunsaturated fatty acid 5-lipoxygenase
Review this target as 5-lipoxygenase/FLAP, mapped to UniProt P09917. ChEMBL maps the protein component as Polyunsaturated fatty acid 5-lipoxygenase. Sequence length is 674 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL29097 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL289751 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL38958 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL3349448 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL39617 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL290170 | 6.82 | IC50 | 150.0 | Preclinical |
| CHEMBL39189 | 6.77 | IC50 | 170.0 | Preclinical |
| CHEMBL36331 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL434401 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL16596 | 6.7 | IC50 | 200.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 10 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 18 | 5.7 |
| tissue-based format | 1 | 19 | 6.3 |