Tyrosine-protein kinase ABL · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P00519. Use UniProt P00519 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00519 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase ABL1
Review this target as Tyrosine-protein kinase ABL, mapped to UniProt P00519. ChEMBL maps the protein component as Tyrosine-protein kinase ABL1. Sequence length is 1130 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase ABL as ChEMBL target CHEMBL2111414, mapped to UniProt P00519. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Tyrosine-protein kinase ABL |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P00519 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase ABL1 |
| UniProt Accession | P00519 |
| Component Type | Protein |
| Sequence Length | 1130 aa |
Tyrosine-protein kinase ABL1
Review this target as Tyrosine-protein kinase ABL, mapped to UniProt P00519. ChEMBL maps the protein component as Tyrosine-protein kinase ABL1. Sequence length is 1130 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL290921 | 9.11 | IC50 | 0.78 | Preclinical |
| CHEMBL288441 | 9.0 | IC50 | 1.0 | Approved |
| CHEMBL373101 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL364955 | 8.64 | IC50 | 2.3 | Preclinical |
| CHEMBL41465 | 8.54 | IC50 | 2.9 | Preclinical |
| CHEMBL42136 | 8.54 | IC50 | 2.9 | Preclinical |
| CHEMBL290664 | 8.46 | IC50 | 3.5 | Preclinical |
| CHEMBL40557 | 8.34 | IC50 | 4.6 | Preclinical |
| CHEMBL355330 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL41633 | 8.08 | IC50 | 8.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 22 | 97 | 6.3 |
| cell-based format | 6 | 0 | — |
| subcellular format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 3 | 8.8 |