Transcription factor AP1 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P05412. Use UniProt P05412 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P05412 as the stable identity anchor, then attach disease evidence before program review.
Transcription factor Jun
Review this target as Transcription factor AP1, mapped to UniProt P05412. ChEMBL maps the protein component as Transcription factor Jun. Sequence length is 331 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Transcription factor AP1 as ChEMBL target CHEMBL2111421, mapped to UniProt P05412. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Transcription factor AP1 is the right protein anchor across sources, using UniProt P05412 as the stable mapping.
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| Preferred Name | Transcription factor AP1 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P05412 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Transcription factor Jun |
| UniProt Accession | P05412 |
| Component Type | Protein |
| Sequence Length | 331 aa |
Transcription factor Jun
Review this target as Transcription factor AP1, mapped to UniProt P05412. ChEMBL maps the protein component as Transcription factor Jun. Sequence length is 331 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL140 | 8.16 | IC50 | 6.9 | Clinical |
| CHEMBL52 | 8.1 | IC50 | 7.9 | Preclinical |
| CHEMBL43549 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL42952 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL43610 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL295192 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL295508 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL42650 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL43534 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL44525 | 6.7 | IC50 | 200.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 8 | 19 | 5.8 |
| cell-based format | 1 | 4 | 5.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 45 | 5.8 |