Epidermal growth factor receptor and ErbB2 (HER1 and HER2) · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P04626. Use UniProt P04626 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04626 as the stable identity anchor, then attach disease evidence before program review.
Receptor tyrosine-protein kinase erbB-2
Review this target as Epidermal growth factor receptor and ErbB2 (HER1 and HER2), mapped to UniProt P04626. ChEMBL maps the protein component as Receptor tyrosine-protein kinase erbB-2. Sequence length is 1255 aa.
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This review treats Epidermal growth factor receptor and ErbB2 (HER1 and HER2) as ChEMBL target CHEMBL2111431, mapped to UniProt P04626. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Epidermal growth factor receptor and ErbB2 (HER1 and HER2) |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P04626 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Receptor tyrosine-protein kinase erbB-2 |
| UniProt Accession | P04626 |
| Component Type | Protein |
| Sequence Length | 1255 aa |
Receptor tyrosine-protein kinase erbB-2
Review this target as Epidermal growth factor receptor and ErbB2 (HER1 and HER2), mapped to UniProt P04626. ChEMBL maps the protein component as Receptor tyrosine-protein kinase erbB-2. Sequence length is 1255 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL160846 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL155761 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL160303 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL422347 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL157084 | 7.27 | IC50 | 54.0 | Preclinical |
| CHEMBL29197 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL116595 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL1203088 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL109428 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL111038 | 6.72 | IC50 | 190.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 27 | 10 | 5.5 |
| protein format | 6 | 55 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 31 | 5.7 |
| cell-based format | 3 | 6 | — |