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Target Snapshot

CHEMBL2111442 Target Snapshot

Monoamine oxidase · PROTEIN FAMILY · Mus musculus

55Compounds
20Assays
0Approved Drugs
2.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q8BW75. Use UniProt Q8BW75 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8BW75 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Monoamine oxidase as ChEMBL target CHEMBL2111442, mapped to UniProt Q8BW75. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Monoamine oxidase
PROTEIN FAMILY · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL2111442
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q8BW75
Amine oxidase [flavin-containing] B
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Monoamine oxidase is the right protein anchor across sources, using UniProt Q8BW75 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAmine oxidase [flavin-containing] B
UniProt AccessionQ8BW75
Component TypeProtein
Sequence Length520 aa

Amine oxidase [flavin-containing] B

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Monoamine oxidase, mapped to UniProt Q8BW75. ChEMBL maps the protein component as Amine oxidase [flavin-containing] B. Sequence length is 520 aa.

Mapped IDQ8BW75
Review nameMonoamine oxidase
OrganismMus musculus
Assay Mix

Activity Type Distribution

IC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL461985 5.97 IC50 1060.0 Preclinical
CHEMBL238628 4.59 IC50 25800.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

20
Total Assays
2
Tested Compounds
2
Assay Types
Binding — 15 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 7 0
assay format 3 1 6.0
protein format 3 0
mitochondrion format 1 1 4.6
organism-based format 1 0
Functional — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 3 0
assay format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine