CDK6/cyclin D3 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P30281. Use UniProt P30281 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P30281 as the stable identity anchor, then attach disease evidence before program review.
G1/S-specific cyclin-D3
Review this target as CDK6/cyclin D3, mapped to UniProt P30281. ChEMBL maps the protein component as G1/S-specific cyclin-D3. Sequence length is 292 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats CDK6/cyclin D3 as ChEMBL target CHEMBL2111448, mapped to UniProt P30281. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | CDK6/cyclin D3 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P30281 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | G1/S-specific cyclin-D3 |
| UniProt Accession | P30281 |
| Component Type | Protein |
| Sequence Length | 292 aa |
G1/S-specific cyclin-D3
Review this target as CDK6/cyclin D3, mapped to UniProt P30281. ChEMBL maps the protein component as G1/S-specific cyclin-D3. Sequence length is 292 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5970111 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4285830 | 9.41 | IC50 | 0.39 | Preclinical |
| CHEMBL5739950 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5876670 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL4279832 | 9.31 | IC50 | 0.49 | Preclinical |
| CHEMBL4277900 | 9.14 | IC50 | 0.73 | Clinical |
| CHEMBL5749795 | 9.05 | Ki | 0.9 | Preclinical |
| CHEMBL5903827 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL4281514 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5816600 | 9.0 | Ki | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 161 | 436 | 7.5 |
| cell-based format | 22 | 58 | 6.8 |
| assay format | 12 | 66 | 7.5 |
| single protein format | 3 | 5 | 5.8 |