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Target Snapshot

CHEMBL2111452 Target Snapshot

Alpha-1 adrenergic receptor · PROTEIN FAMILY · Mus musculus

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46Compounds
19Assays
1Approved Drugs
25.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P97714. Use UniProt P97714 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P97714 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Alpha-1 adrenergic receptor as ChEMBL target CHEMBL2111452, mapped to UniProt P97714. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Alpha-1 adrenergic receptor
PROTEIN FAMILY · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2111452
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P97714
Alpha-1D adrenergic receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Alpha-1 adrenergic receptor is the right protein anchor across sources, using UniProt P97714 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAlpha-1 adrenergic receptor
Target TypePROTEIN FAMILY
OrganismMus musculus
UniProtP97714
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAlpha-1D adrenergic receptor
UniProt AccessionP97714
Component TypeProtein
Sequence Length562 aa

Alpha-1D adrenergic receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Alpha-1 adrenergic receptor, mapped to UniProt P97714. ChEMBL maps the protein component as Alpha-1D adrenergic receptor. Sequence length is 562 aa.

Mapped IDP97714
Review nameAlpha-1 adrenergic receptor
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5024.0
KI1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL836 8.74 IC50 1.8 Approved
CHEMBL4129927 7.22 IC50 60.0 Preclinical
CHEMBL4126353 6.46 IC50 348.0 Preclinical
CHEMBL4126498 6.24 IC50 577.0 Preclinical
CHEMBL4129778 6.15 IC50 711.0 Preclinical
CHEMBL4128701 5.97 IC50 1066.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
3
6.0
0
6.5
1
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TAMSULOSIN
CHEMBL836
Approved 1997
Properties Compare Identifier
Assay Landscape

Assay Landscape

19
Total Assays
6
Tested Compounds
3
Assay Types
ADME — 13 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 13 6 6.8
Binding — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 3 0 —
Functional — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 3 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine