Endothelin receptor · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P26684. Use UniProt P26684 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P26684 as the stable identity anchor, then attach disease evidence before program review.
Endothelin-1 receptor
Review this target as Endothelin receptor, mapped to UniProt P26684. ChEMBL maps the protein component as Endothelin-1 receptor. Sequence length is 426 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Endothelin receptor as ChEMBL target CHEMBL2111453, mapped to UniProt P26684. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Endothelin receptor is the right protein anchor across sources, using UniProt P26684 as the stable mapping.
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| Preferred Name | Endothelin receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P26684 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Endothelin-1 receptor |
| UniProt Accession | P26684 |
| Component Type | Protein |
| Sequence Length | 426 aa |
Endothelin-1 receptor
Review this target as Endothelin receptor, mapped to UniProt P26684. ChEMBL maps the protein component as Endothelin-1 receptor. Sequence length is 426 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL9194 | 10.4 | IC50 | 0.04 | Clinical |
| CHEMBL8923 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL9139 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL9334 | 9.6 | IC50 | 0.25 | Preclinical |
| CHEMBL9119 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL9502 | 9.48 | IC50 | 0.33 | Preclinical |
| CHEMBL266354 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL319754 | 9.03 | Kd | 0.9333 | Preclinical |
| CHEMBL267695 | 9.01 | IC50 | 0.97 | Preclinical |
| CHEMBL267279 | 9.0 | IC50 | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 13 | 0 | — |
| assay format | 3 | 34 | 7.5 |
| cell-based format | 1 | 21 | 8.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 3 | 3 | 5.5 |
| protein format | 2 | 27 | 5.7 |