Opioid receptor (mu and kappa) · SELECTIVITY GROUP · Cavia porcellus
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P41144. Use UniProt P41144 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P41144 as the stable identity anchor, then attach disease evidence before program review.
Kappa-type opioid receptor
Review this target as Opioid receptor (mu and kappa), mapped to UniProt P41144. ChEMBL maps the protein component as Kappa-type opioid receptor. Sequence length is 380 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Opioid receptor (mu and kappa) as ChEMBL target CHEMBL2111465, mapped to UniProt P41144. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Opioid receptor (mu and kappa) is the right protein anchor across sources, using UniProt P41144 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Opioid receptor (mu and kappa) |
| Target Type | SELECTIVITY GROUP |
| Organism | Cavia porcellus |
| UniProt | P41144 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Kappa-type opioid receptor |
| UniProt Accession | P41144 |
| Component Type | Protein |
| Sequence Length | 380 aa |
Kappa-type opioid receptor
Review this target as Opioid receptor (mu and kappa), mapped to UniProt P41144. ChEMBL maps the protein component as Kappa-type opioid receptor. Sequence length is 380 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL440446 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL263597 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL266515 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL415330 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL266717 | 9.6 | IC50 | 0.25 | Preclinical |
| CHEMBL440987 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL415617 | 9.57 | IC50 | 0.27 | Preclinical |
| CHEMBL263583 | 9.47 | IC50 | 0.34 | Preclinical |
| CHEMBL438741 | 9.19 | IC50 | 0.64 | Preclinical |
| CHEMBL607010 | 7.28 | IC50 | 53.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 6 | 0 | — |
| tissue-based format | 6 | 0 | — |
| assay format | 3 | 0 | — |
| cell membrane format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 6 | 12 | 8.6 |
| assay format | 2 | 0 | — |