GABA B receptor · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Z0U4. Use UniProt Q9Z0U4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Z0U4 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid type B receptor subunit 1
Review this target as GABA B receptor, mapped to UniProt Q9Z0U4. ChEMBL maps the protein component as Gamma-aminobutyric acid type B receptor subunit 1. Sequence length is 960 aa.
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This review treats GABA B receptor as ChEMBL target CHEMBL2111474, mapped to UniProt Q9Z0U4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | GABA B receptor |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | Q9Z0U4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid type B receptor subunit 1 |
| UniProt Accession | Q9Z0U4 |
| Component Type | Protein |
| Sequence Length | 960 aa |
Gamma-aminobutyric acid type B receptor subunit 1
Review this target as GABA B receptor, mapped to UniProt Q9Z0U4. ChEMBL maps the protein component as Gamma-aminobutyric acid type B receptor subunit 1. Sequence length is 960 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL112710 | 10.8 | IC50 | 0.016 | Preclinical |
| CHEMBL112203 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL96 | 7.77 | IC50 | 17.0 | Preclinical |
| CHEMBL701 | 7.52 | IC50 | 30.0 | Approved |
| CHEMBL301742 | 7.5 | IC50 | 32.0 | Clinical |
| CHEMBL545424 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL553273 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL113310 | 7.35 | IC50 | 45.0 | Preclinical |
| CHEMBL32102 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL321255 | 7.19 | IC50 | 65.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 8 | 16 | 5.7 |
| cell membrane format | 7 | 13 | 6.5 |
| assay format | 3 | 20 | 6.7 |
| tissue-based format | 3 | 0 | — |
| subcellular format | 1 | 7 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 1 | — |