Use UniProt Q60613 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL2115 Target Snapshot
Adenosine receptor A2a · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q60613. Use UniProt Q60613 as the stable identity anchor, then attach disease evidence before program review.
Adenosine receptor A2a
Review this target as Adenosine receptor A2a, mapped to UniProt Q60613. Sequence length is 410 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Adenosine receptor A2a as ChEMBL target CHEMBL2115, mapped to UniProt Q60613. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Adenosine receptor A2a |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q60613 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Adenosine receptor A2a |
| UniProt Accession | Q60613 |
| Component Type | Protein |
| Sequence Length | 410 aa |
Adenosine receptor A2a
How to read this target
Review this target as Adenosine receptor A2a, mapped to UniProt Q60613. Sequence length is 410 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL6007478 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5999728 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL5825227 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5827075 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5928153 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL6057843 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL5800386 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL5756623 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL5957422 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL6057896 | 9.1 | IC50 | 0.8 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 17 assays, 127 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 15 | 20 | 5.9 |
| assay format | 1 | 107 | 7.7 |
| cell membrane format | 1 | 0 | — |
Functional — 2 assays, 0 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |
ADME — 1 assays, 0 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |