5'-AMP-activated protein kinase catalytic subunit alpha-2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P54646. Use UniProt P54646 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54646 as the stable identity anchor, then attach disease evidence before program review.
5'-AMP-activated protein kinase catalytic subunit alpha-2
Review this target as 5'-AMP-activated protein kinase catalytic subunit alpha-2, mapped to UniProt P54646. Sequence length is 552 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5'-AMP-activated protein kinase catalytic subunit alpha-2 as ChEMBL target CHEMBL2116, mapped to UniProt P54646. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P54646 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
| UniProt Accession | P54646 |
| Component Type | Protein |
| Sequence Length | 552 aa |
5'-AMP-activated protein kinase catalytic subunit alpha-2
Review this target as 5'-AMP-activated protein kinase catalytic subunit alpha-2, mapped to UniProt P54646. Sequence length is 552 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3969654 | 9.07 | EC50 | 0.86 | Preclinical |
| CHEMBL273453 | 8.89 | EC50 | 1.3 | Clinical |
| CHEMBL3955171 | 8.74 | EC50 | 1.8 | Preclinical |
| CHEMBL3970694 | 8.74 | EC50 | 1.8 | Preclinical |
| CHEMBL3895006 | 8.55 | EC50 | 2.8 | Preclinical |
| CHEMBL3955631 | 8.52 | EC50 | 3.0 | Preclinical |
| CHEMBL3983813 | 8.48 | EC50 | 3.3 | Preclinical |
| CHEMBL3904401 | 8.44 | EC50 | 3.6 | Preclinical |
| CHEMBL1908395 | 8.39 | Kd | 4.1 | Preclinical |
| CHEMBL3929875 | 8.29 | EC50 | 5.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 119 | 163 | 6.1 |
| cell-based format | 26 | 4 | 6.1 |
| assay format | 18 | 19 | 8.0 |
| subcellular format | 17 | 0 | — |