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Evidence Snapshot

Fibroblast growth factor 1

CHEMBL2120 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T00:48:05Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2120
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Fibroblast growth factor 1 as ChEMBL target CHEMBL2120, mapped to UniProt P05230. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Fibroblast growth factor 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2120
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P05230
Fibroblast growth factor 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Fibroblast growth factor 1 matters

As of 2026-09-14

Fibroblast growth factor 1 is reviewed as Fibroblast growth factor 1 (UniProt P05230); Fibroblast growth factor 1 shows late clinical disease relevance led by prostate cancer. 5 more disease programs remain visible in the same review block.; 2 linked drugs keep this evidence frame grounded.; the current evidence base includes 0 approved drugs, 125 compounds, and 13 assays, with lead potency reaching pChEMBL 9.9.

Disease context
prostate cancer

Fibroblast growth factor 1 shows late clinical disease relevance led by prostate cancer. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include MUPARFOSTAT, SURAMIN HEXASODIUM.

Start review with prostate cancer because it currently carries late clinical support. Linked drugs include MUPARFOSTAT, SURAMIN HEXASODIUM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Late clinical 2 linked drugs
Activity base
Portfolio and assay base

ChEMBL currently tracks 0 approved drugs, 125 compounds, and 13 assays for this target. The dominant activity type is KD. CHEMBL382044 is the current potency anchor at pChEMBL 9.9.

Use CHEMBL382044 as the tractability anchor when discussing potency (pChEMBL 9.9).

Activity source · ChEMBL 36 via Core Engine
pChEMBL 9.9
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Fibroblast growth factor 1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P05230, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why prostate cancer is currently treated as late clinical support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

125
Total Compounds
13
Total Assays
0
Approved Drugs
IC50: 2.0, KD: 113.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL382044
 9.9 Kd —
No preferred name
CHEMBL198643
 9.8 Kd —
No preferred name
CHEMBL2059243
 9.6 Kd —
No preferred name
CHEMBL262707
 9.4 Kd —
No preferred name
CHEMBL2059242
 9.4 Kd —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T00:48:05Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2120